A highly virulent variant of HIV-1 circulating in the Netherlands (2024)

A highly virulent variant of HIV-1 circulating in the Netherlands (1) https://doi.org/10.1126/science.abk1688 · A highly virulent variant of HIV-1 circulating in the Netherlands (2)

Видання: Science, 2022, №6580, с.540-545

Видавець: American Association for the Advancement of Science (AAAS)

Автори:

  1. Chris Wymant
  2. Daniela Bezemer
  3. François Blanquart
  4. Luca Ferretti
  5. Astrid Gall
  6. Matthew Hall
  7. Tanya Golubchik
  8. Margreet Bakker
  9. Swee Hoe Ong
  10. Lele Zhao
  11. David Bonsall
  12. Mariateresa de Cesare
  13. George MacIntyre-co*ckett
  14. Lucie Abeler-Dörner
  15. Jan Albert
  16. Norbert Bannert
  17. Jacques Fellay
  18. M. Kate Grabowski
  19. Barbara Gunsenheimer-Bartmeyer
  20. Huldrych F. Günthard
  21. Pia Kivelä
  22. Roger D. Kouyos
  23. Oliver Laeyendecker
  24. Laurence Meyer
  25. Kholoud Porter
  26. Matti Ristola
  27. Ard van Sighem
  28. Ben Berkhout
  29. Paul Kellam
  30. Marion Cornelissen
  31. Peter Reiss
  32. Christophe Fraser
  33. V. Aubert
  34. M. Battegay
  35. E. Bernasconi
  36. J. Böni
  37. D. L. Braun
  38. H. C. Bucher
  39. C. Burton-Jeangros
  40. A. Calmy
  41. M. Cavassini
  42. G. Dollenmaier
  43. M. Egger
  44. L. Elzi
  45. J. Fehr
  46. J. Fellay
  47. H. Furrer
  48. C. A. f*ck
  49. M. Gorgievski
  50. H. Günthard
  51. D. Haerry
  52. B. Hasse
  53. H. H. Hirsch
  54. M. Hoffmann
  55. I. Hösli
  56. C. Kahlert
  57. L. Kaiser
  58. O. Keiser
  59. T. Klimkait
  60. R. Kouyos
  61. H. Kovari
  62. B. Ledergerber
  63. G. Martinetti
  64. B. Martinez de Tejada
  65. C. Marzolini
  66. K. Metzner
  67. N. Müller
  68. D. Nadal
  69. D. Nicca
  70. G. Pantaleo
  71. A. Rauch
  72. S. Regenass
  73. C. Rudin
  74. F. Schöni-Affolter
  75. P. Schmid
  76. R. Speck
  77. M. Stöckle
  78. P. Tarr
  79. A. Trkola
  80. P. Vernazza
  81. R. Weber
  82. S. Yerly
  83. M. van der Valk
  84. S. E. Geerlings
  85. A. Goorhuis
  86. J. W. Hovius
  87. B. Lempkes
  88. F. J. B. Nellen
  89. T. van der Poll
  90. J. M. Prins
  91. P. Reiss
  92. M. van Vugt
  93. W. J. Wiersinga
  94. F. W. M. N. Wit
  95. M. van Duinen
  96. J. van Eden
  97. A. Hazenberg
  98. A. M. H. van Hes
  99. F. J. J. Pijnappel
  100. S. Y. Smalhout
  101. A. M. Weijsenfeld
  102. S. Jurriaans
  103. N. K. T. Back
  104. H. L. Zaaijer
  105. B. Berkhout
  106. M. T. E. Cornelissen
  107. C. J. Schinkel
  108. K. C. Wolthers
  109. E. J. G. Peters
  110. M. A. van Agtmael
  111. R. S. Autar
  112. M. Bomers
  113. K. C. E. Sigaloff
  114. M. Heitmuller
  115. L. M. Laan
  116. C. W. Ang
  117. R. van Houdt
  118. M. Jonges
  119. T. W. Kuijpers
  120. D. Pajkrt
  121. H. J. Scherpbier
  122. C. de Boer
  123. A. van der Plas
  124. M. van den Berge
  125. A. Stegeman
  126. S. Baas
  127. L. Hage de Looff
  128. A. Buiting
  129. A. Reuwer
  130. J. Veenemans
  131. B. Wintermans
  132. M. J. H. Pronk
  133. H. S. M. Ammerlaan
  134. D. N. J. van den Bersselaar
  135. E. S. de Munnik
  136. B. Deiman
  137. A. R. Jansz
  138. V. Scharnhorst
  139. J. Tjhie
  140. M. C. A. Wegdam
  141. A. van Eeden
  142. J. Nellen
  143. W. Brokking
  144. L. J. M. Elsenburg
  145. H. Nobel
  146. M. E. E. van Kasteren
  147. M. A. H. Berrevoets
  148. A. E. Brouwer
  149. A. Adams
  150. R. van Erve
  151. B. A. F. M. de Kruijf-van de Wiel
  152. S. Keelan-Phaf
  153. B. van de Ven
  154. B. van der Ven
  155. A. G. M. Buiting
  156. J. L. Murck
  157. T. E. M. S. de Vries-Sluijs
  158. H. I. Bax
  159. E. C. M. van Gorp
  160. N. C. de Jong-Peltenburg
  161. M. de Mendonç̧a Melo
  162. E. van Nood
  163. J. L. Nouwen
  164. B. J. A. Rijnders
  165. C. Rokx
  166. C. A. M. Schurink
  167. L. Slobbe
  168. A. Verbon
  169. N. Bassant
  170. J. E. A. van Beek
  171. M. Vriesde
  172. L. M. van Zonneveld
  173. J. de Groot
  174. C. A. B. Boucher
  175. M. P. G. Koopmans
  176. J. J. A. van Kampen
  177. P. L. A. Fraaij
  178. A. M. C. van Rossum
  179. C. L. Vermont
  180. L. C. van der Knaap
  181. E. Visser
  182. J. Branger
  183. R. A. Douma
  184. A. S. Cents-Bosma
  185. C. J. H. M. Duijf-van de Ven
  186. E. F. Schippers
  187. C. van Nieuwkoop
  188. J. M. van Ijperen
  189. J. Geilings
  190. G. van der Hut
  191. N. D. van Burgel
  192. E. M. S. Leyten
  193. L. B. S. Gelinck
  194. F. Mollema
  195. S. Davids-Veldhuis
  196. C. Tearno
  197. G. S. Wildenbeest
  198. E. Heikens
  199. P. H. P. Groeneveld
  200. J. W. Bouwhuis
  201. A. J. J. Lammers
  202. S. Kraan
  203. A. G. W. van Hulzen
  204. M. S. M. Kruiper
  205. G. L. van der Bliek
  206. P. C. J. Bor
  207. S. B. Debast
  208. G. H. J. Wagenvoort
  209. F. P. Kroon
  210. M. G. J. de Boer
  211. H. Jolink
  212. M. M. C. Lambregts
  213. A. H. E. Roukens
  214. H. Scheper
  215. W. Dorama
  216. N. van Holten
  217. E. C. J. Claas
  218. E. Wessels
  219. J. G. den Hollander
  220. R. El Moussaoui
  221. K. Pogany
  222. C. J. Brouwer
  223. J. V. Smit
  224. D. Struik-Kalkman
  225. T. van Niekerk
  226. O. Pontesilli
  227. S. H. Lowe
  228. A. M. L. Oude Lashof
  229. D. Posthouwer
  230. M. E. van Wolfswinkel
  231. R. P. Ackens
  232. K. Burgers
  233. J. Schippers
  234. B. Weijenberg-Maes
  235. I. H. M. van Loo
  236. T. R. A. Havenith
  237. M. G. A. van Vonderen
  238. L. M. Kampschreur
  239. S. Faber
  240. R. Steeman-Bouma
  241. A. Al Moujahid
  242. G. J. Kootstra
  243. C. E. Delsing
  244. M. van der Burg-van de Plas
  245. L. Scheiberlich
  246. W. Kortmann
  247. G. van Twillert
  248. R. Renckens
  249. D. Ruiter-Pronk
  250. F. A. van Truijen-Oud
  251. J. W. T. Cohen Stuart
  252. ER. Jansen
  253. M. Hoogewerf
  254. W. Rozemeijer
  255. W. A. van der Reijden
  256. J. C. Sinnige
  257. K. Brinkman
  258. G. E. L. van den Berk
  259. W. L. Blok
  260. K. D. Lettinga
  261. M. de Regt
  262. W. E. M. Schouten
  263. J. E. Stalenhoef
  264. J. Veenstra
  265. S. M. E. Vrouenraets
  266. H. Blaauw
  267. G. F. Geerders
  268. M. J. Kleene
  269. M. Kok
  270. M. Knapen
  271. I. B. van der Meché
  272. E. Mulder-Seeleman
  273. A. J. M. Toonen
  274. S. Wijnands
  275. E. Wttewaal
  276. D. Kwa
  277. R. van Crevel
  278. K. van Aerde
  279. A. S. M. Dofferhoff
  280. S. S. V. Henriet
  281. H. J. M. ter Hofstede
  282. J. Hoogerwerf
  283. M. Keuter
  284. O. Richel
  285. M. Albers
  286. K. J. T. Grintjes-Huisman
  287. M. de Haan
  288. M. Marneef
  289. R. Strik-Albers
  290. J. Rahamat-Langendoen
  291. F. F. Stelma
  292. D. Burger
  293. E. H. Gisolf
  294. R. J. Hassing
  295. M. Claassen
  296. G. ter Beest
  297. P. H. M. van Bentum
  298. N. Langebeek
  299. R. Tiemessen
  300. C. M. A. Swanink
  301. S. F. L. van Lelyveld
  302. R. Soetekouw
  303. L. M. M. van der Prijt
  304. J. van der Swaluw
  305. N. Bermon
  306. W. A. van der Reijden
  307. R. Jansen
  308. B. L. Herpers
  309. D. Veenendaal
  310. D. W. M. Verhagen
  311. F. N. Lauw
  312. M. C. van Broekhuizen
  313. M. van Wijk
  314. W. F. W. Bierman
  315. M. Bakker
  316. J. Kleinnijenhuis
  317. E. Kloeze
  318. A. Middel
  319. D. F. Postma
  320. E. H. Schölvinck
  321. Y. Stienstra
  322. A. R. Verhage
  323. M. Wouthuyzen-Bakker
  324. A. Boonstra
  325. H. de Groot-de Jonge
  326. P. A. van der Meulen
  327. D. A. de Weerd
  328. H. G. M. Niesters
  329. C. C. van Leer-Buter
  330. M. Knoester
  331. A. I. M. Hoepelman
  332. J. E. Arends
  333. R. E. Barth
  334. A. H. W. Bruns
  335. P. M. Ellerbroek
  336. T. Mudrikova
  337. J. J. Oosterheert
  338. E. M. Schadd
  339. B. J. van Welzen
  340. K. Aarsman
  341. B. M. G. Griffioen-van Santen
  342. I. de Kroon
  343. M. van Berkel
  344. C. S. A. M. van Rooijen
  345. R. Schuurman
  346. F. Verduyn-Lunel
  347. A. M. J. Wensing
  348. L. J. Bont
  349. S. P. M. Geelen
  350. Y. G. T. Loeffen
  351. T. F. W. Wolfs
  352. N. Nauta
  353. E. O. W. Rooijakkers
  354. H. Holtsema
  355. R. Voigt
  356. D. van de Wetering
  357. A. Alberto
  358. I. van der Meer
  359. A. Rosingh
  360. T. Halaby
  361. S. Zaheri
  362. A. C. Boyd
  363. D. O. Bezemer
  364. A. I. van Sighem
  365. C. Smit
  366. M. Hillebregt
  367. A. de Jong
  368. T. Woudstra
  369. D. Bergsma
  370. R. Meijering
  371. L. van de Sande
  372. T. Rutkens
  373. S. van der Vliet
  374. L. de Groot
  375. M. van den Akker
  376. Y. Bakker
  377. A. El Berkaoui
  378. M. Bezemer
  379. N. Brétin
  380. E. Djoechro
  381. M. Groters
  382. E. Kruijne
  383. K. J. Lelivelt
  384. C. Lodewijk
  385. E. Lucas
  386. L. Munjishvili
  387. F. Paling
  388. B. Peeck
  389. C. Ree
  390. R. Regtop
  391. Y. Ruijs
  392. M. Schoorl
  393. P. Schnörr
  394. A. Scheigrond
  395. E. Tuijn
  396. L. Veenenberg
  397. K. M. Visser
  398. E. C. Witte
  399. Y. Ruijs
  400. Maartje Van Frankenhuijsen
  401. Thierry Allegre
  402. Djamila Makhloufi
  403. Jean-Michel Livrozet
  404. Pierre Chiarello
  405. Mathieu Godinot
  406. Florence Brunel-Dalmas
  407. Sylvie Gibert
  408. Christian Trepo
  409. Dominique Peyramond
  410. Patrick Miailhes
  411. Joseph Koffi
  412. Valérie Thoirain
  413. Corinne Brochier
  414. Thomas Baudry
  415. Sylvie Pailhes
  416. Alain Lafeuillade
  417. Gisèle Philip
  418. Gilles Hittinger
  419. Assi Assi
  420. Véronique Lambry
  421. Eric Rosenthal
  422. Alissa Naqvi
  423. Brigitte Dunais
  424. Eric Cua
  425. Christian Pradier
  426. Jacques Durant
  427. Aline Joulie
  428. Denis Quinsat
  429. Serge Tempesta
  430. Isabelle Ravaux
  431. Isabelle Poizot Martin
  432. Olivia Faucher
  433. Nicolas Cloarec
  434. Hélène Champagne
  435. Gilles Pichancourt
  436. Philippe Morlat
  437. Thierry Pistone
  438. Fabrice Bonnet
  439. Patrick Mercie
  440. Isabelle Faure
  441. Mojgan Hessamfar
  442. Denis Malvy
  443. Denis Lacoste
  444. Marie-Carmen Pertusa
  445. Marie-Anne Vandenhende
  446. Noëlle Bernard
  447. François Paccalin
  448. Cédric Martell
  449. Julien Roger-Schmelz
  450. Marie-Catherine Receveur
  451. Pierre Duffau
  452. Denis Dondia
  453. Emmanuel Ribeiro
  454. Sabrina Caltado
  455. Didier Neau
  456. Michel Dupont
  457. Hervé Dutronc
  458. Frédéric Dauchy
  459. Charles Cazanave
  460. Marc-Olivier Vareil
  461. Gaétane Wirth
  462. Séverine Le Puil
  463. Jean-Luc Pellegrin
  464. Isabelle Raymond
  465. Jean-François Viallard
  466. Severin Chaigne de Lalande
  467. Daniel Garipuy
  468. Pierre Delobel
  469. Martine Obadia
  470. Lise Cuzin
  471. Muriel Alvarez
  472. Noemie Biezunski
  473. Lydie Porte
  474. Patrice Massip
  475. Alexa Debard
  476. Florence Balsarin
  477. Myriam Lagarrigue
  478. François Prevoteau du Clary
  479. Christian Aquilina
  480. Jacques Reynes
  481. Vincent Baillat
  482. Corinne Merle
  483. Vincent Lemoing
  484. Nadine Atoui
  485. Alain Makinson
  486. Jean Marc Jacquet
  487. Christina Psomas
  488. Christine Tramoni
  489. Hugues Aumaitre
  490. Mathieu Saada
  491. Marie Medus
  492. Martine Malet
  493. Aurélia Eden
  494. Ségolène Neuville
  495. Milagros Ferreyra
  496. Albert Sotto
  497. Claudine Barbuat
  498. Isabelle Rouanet
  499. Didier Leureillard
  500. Jean-Marc Mauboussin
  501. Catherine Lechiche
  502. Régine Donsesco
  503. André Cabie
  504. Sylvie Abel
  505. Sandrine Pierre-Francois
  506. Anne-Sophie Batala
  507. Christophe Cerland
  508. Camille Rangom
  509. Nadine Theresine
  510. Bruno Hoen
  511. Isabelle Lamaury
  512. Isabelle Fabre
  513. Kinda Schepers
  514. Elodie Curlier
  515. Rachida Ouissa
  516. Catherine Gaud
  517. Carole Ricaud
  518. Roland Rodet
  519. Guillaume Wartel
  520. Carmele Sautron
  521. Geneviève Beck-Wirth
  522. Catherine Michel
  523. Charles Beck
  524. Jean-Michel Halna
  525. Jakub Kowalczyk
  526. Meryem Benomar
  527. Christine Drobacheff-Thiebaut
  528. Catherine Chirouze
  529. Jean-François Faucher
  530. François Parcelier
  531. Adeline Foltzer
  532. Cécile Haffner-Mauvais
  533. Mathieu Hustache Mathieu
  534. Aurélie Proust
  535. Lionel Piroth
  536. Pascal Chavanet
  537. Michel Duong
  538. Marielle Buisson
  539. Anne Waldner
  540. Sophie Mahy
  541. Sandrine Gohier
  542. Delphine Croisier
  543. Thierry May
  544. Mikael Delestan
  545. Marie Andre
  546. Mahsa Mohseni Zadeh
  547. Martin Martinot
  548. Béatrice Rosolen
  549. Anne Pachart
  550. Benoît Martha
  551. Noëlle Jeunet
  552. David Rey
  553. Christine Cheneau
  554. Maria Partisani
  555. Michèle Priester
  556. Claudine Bernard-Henry
  557. Marie-Laure Batard
  558. Patricia Fischer
  559. Jean-Luc Berger
  560. Isabelle Kmiec
  561. Olivier Robineau
  562. Thomas Huleux
  563. Faïza Ajana
  564. Isabelle Alcaraz
  565. Christophe Allienne
  566. Véronique Baclet
  567. Agnès Meybeck
  568. Michel Valette
  569. Nathalie Viget
  570. Emmanuelle Aissi
  571. Raphael Biekre
  572. Pauline Cornavin
  573. Dominique Merrien
  574. Jean-Christophe Seghezzi
  575. Moise Machado
  576. Georges Diab
  577. François Raffi
  578. Bénédicte Bonnet
  579. Clotilde Allavena
  580. Olivier Grossi
  581. Véronique Reliquet
  582. Eric Billaud
  583. Cecile Brunet
  584. Sabelline Bouchez
  585. Pascale Morineau-Le Houssine
  586. Fabienne Sauser
  587. David Boutoille
  588. Michel Besnier
  589. Hervé Hue
  590. Nolwenn Hall
  591. Delphine Brosseau
  592. Faouzi Souala
  593. Christian Michelet
  594. Pierre Tattevin
  595. Cédric Arvieux
  596. Matthieu Revest
  597. Helene Leroy
  598. Jean-Marc Chapplain
  599. Matthieu Dupont
  600. Fabien Fily
  601. Solène Patra-Delo
  602. Céline Lefeuvre
  603. Louis Bernard
  604. Frédéric Bastides
  605. Pascale Nau
  606. Renaud Verdon
  607. Arnaud de la Blanchardiere
  608. Anne Martin
  609. Philippe Feret
  610. Loïk Geffray
  611. Corinne Daniel
  612. Jennifer Rohan
  613. Pascale Fialaire
  614. Jean Marie Chennebault
  615. Valérie Rabier
  616. Pierre Abgueguen
  617. Sami Rehaiem
  618. Odile Luycx
  619. Mathilde Niault
  620. Philippe Moreau
  621. Yves Poinsignon
  622. Marie Goussef
  623. Virginie Mouton-Rioux
  624. Dominique Houlbert
  625. Sandrine Alvarez-Huve
  626. Frédérique Barbe
  627. Sophie Haret
  628. Philippe Perre
  629. Sophie Leantez-Nainville
  630. Jean-Luc Esnault
  631. Thomas Guimard
  632. Isabelle Suaud
  633. Jean-Jacques Girard
  634. Véronique Simonet
  635. Yasmine Debab
  636. Jean-Luc Schmit
  637. Christine Jacomet
  638. Pierre Weinberck
  639. Claire Genet
  640. Pauline Pinet
  641. Sophie Ducroix
  642. Hélène Durox
  643. Éric Denes
  644. Bruno Abraham
  645. Florence Gourdon
  646. Odile Antoniotti
  647. Jean-Michel Molina
  648. Samuel Ferret
  649. Caroline Lascoux-Combe
  650. Matthieu Lafaurie
  651. Nathalie Colin de Verdiere
  652. Diane Ponscarme
  653. Nathalie De Castro
  654. Alexandre Aslan
  655. Willy Rozenbaum
  656. Claire Pintado
  657. François Clavel
  658. Olivier Taulera
  659. Caroline Gatey
  660. Anne-Lise Munier
  661. Sandrine Gazaigne
  662. Pauline Penot
  663. Guillaume Conort
  664. Nathalie Lerolle
  665. Anne Leplatois
  666. Stéphanie Balausine
  667. Jeannine Delgado
  668. Julie Timsit
  669. Magda Tabet
  670. Laurence Gerard
  671. Pierre-Marie Girard
  672. Odile Picard
  673. Jürgen Tredup
  674. Diane Bollens
  675. Nadia Valin
  676. Pauline Campa
  677. Julie Bottero
  678. Benedicte Lefebvre
  679. Muriel Tourneur
  680. Laurent Fonquernie
  681. Charlotte Wemmert
  682. Jean-Luc Lagneau
  683. Yazdan Yazdanpanah
  684. Bao Phung
  685. Adriana Pinto
  686. Dorothée Vallois
  687. Ornella Cabras
  688. Françoise Louni
  689. Gilles Pialoux
  690. Thomas Lyavanc
  691. Valérie Berrebi
  692. Julie Chas
  693. Sophie Lenagat
  694. Agathe Rami
  695. Myriam Diemer
  696. Maguy Parrinello
  697. Audrey Depond
  698. Dominique Salmon
  699. Loïc Guillevin
  700. Tassadit Tahi
  701. Linda Belarbi
  702. Pierre Loulergue
  703. Olivier Zak Dit Zbar
  704. Odile Launay
  705. Benjamin Silbermann
  706. Catherine Leport
  707. Laura Alagna
  708. Marie-Pierre Pietri
  709. Anne Simon
  710. Manuela Bonmarchand
  711. Naouel Amirat
  712. François Pichon
  713. Myriam Kirstetter
  714. Christine Katlama
  715. Marc Antoine Valantin
  716. Roland Tubiana
  717. Fabienne Caby
  718. Luminita Schneider
  719. Nadine Ktorza
  720. Ruxandra Calin
  721. Audrey Merlet
  722. Saadia Ben Abdallah
  723. Laurence Weiss
  724. Martin Buisson
  725. Dominique Batisse
  726. Marina Karmochine
  727. Juliette Pavie
  728. Catherine Minozzi
  729. Didier Jayle
  730. Philippe Castel
  731. Jean Derouineau
  732. Pascale Kousignan
  733. Murielle Eliazevitch
  734. Isabelle Pierre
  735. Lio Collias
  736. Jean-Paul Viard
  737. Jacques Gilquin
  738. Alain Sobel
  739. Laurence Slama
  740. Jade Ghosn
  741. Blanka Hadacek
  742. Nugyen Thu-Huyn
  743. Lella Nait-Ighil
  744. Agnes Cros
  745. Aline Maignan
  746. Claudine Duvivier
  747. Paul Henri Consigny
  748. Fanny Lanternier
  749. Michka Shoai-Tehrani
  750. Fatima Touam
  751. Saadia Jerbi
  752. Loïc Bodard
  753. Corinne Jung
  754. Cécile Goujard
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  769. Sophie Abgrall
  770. Imad Kansau
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  775. Dhiba Marigot
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  777. Alain Devidas
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  780. Nouara Agher
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  784. Olivier Bouchaud
  785. Patricia Honore
  786. Elisabeth Rouveix
  787. Evelyne Reimann
  788. Alix Greder Belan
  789. Claire Godin Collet
  790. Safia Souak
  791. Emmanuel Mortier
  792. Martine Bloch
  793. Anne-Marie Simonpoli
  794. Véronique Manceron
  795. Isabelle Cahitte
  796. Emmanuel Hiraux
  797. Erik Lafon
  798. François Cordonnier
  799. Ai-feng Zeng
  800. David Zucman
  801. Catherine Majerholc
  802. Dominique Bornarel
  803. Agnès Uludag
  804. Justine Gellen-Dautremer
  805. Agnès Lefort
  806. Christine Bazin
  807. Vincent Daneluzzi
  808. Juliette Gerbe
  809. Vincent Jeantils
  810. Mélissa Coupard
  811. Olivier Patey
  812. Jonas Bantsimba
  813. Sophie Delllion
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  820. Daniel Vittecoq
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  822. Annie Lepretre
  823. Philippe Genet
  824. Virginie Masse
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  826. Jean-Luc Boussard
  827. Patricia Chardon
  828. Eric Froguel
  829. Philippe Simon
  830. Sylvie Tassi
  831. Véronique Avettand Fenoel
  832. Francis Barin
  833. Christine Bourgeois
  834. Fanny Cardon
  835. Marie-Laure Chaix
  836. Jean François Delfraissy
  837. Asma Essat
  838. Hugues Fischer
  839. Camille Lecuroux
  840. Laurence Meyer
  841. Ventzislava Petrov-Sanchez
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  855. Sue Faulkner
  856. Rebecca Faville
  857. Sandra Herman
  858. Christine Care
  859. Helen Blackman
  860. Katharine Bellenger
  861. Keith Fairbrother
  862. Andrew Phillips
  863. Abdel Babiker
  864. Valerie Delpech
  865. Sarah Fidler
  866. Mindy Clarke
  867. Julie Fox
  868. Richard Gilson
  869. David Goldberg
  870. David Hawkins
  871. Anne Johnson
  872. Margaret Johnson
  873. Ken McLean
  874. Eleni Nastouli
  875. Frank Post
  876. N. Kennedy
  877. J. Pritchard
  878. U. Andrady
  879. N. Rajda
  880. C. Donnelly
  881. S. McKernan
  882. S. Drake
  883. G. Gilleran
  884. D. White
  885. J. Ross
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  887. R. Faville
  888. J. Sweeney
  889. P. Flegg
  890. S. Toomer
  891. H. Wilding
  892. R. Woodward
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  894. C. Richardson
  895. N. Perry
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  897. L. Jennings
  898. D. Bansaal
  899. M. Browing
  900. L. Connolly
  901. B. Stanley
  902. S. Estreich
  903. A. Magdy
  904. C. O’Mahony
  905. P. Fraser
  906. S. P. R Jebakumar
  907. L. David
  908. R. Mette
  909. H. Summerfield
  910. M. Evans
  911. C. White
  912. R. Robertson
  913. C. Lean
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  915. A. Winter
  916. S. Faulkner
  917. B. Goorney
  918. L. Howard
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  920. C. Stemp
  921. L. Short
  922. M. Gomez
  923. F. Young
  924. M. Roberts
  925. S. Green
  926. K. Sivakumar
  927. J. Minton
  928. A. Siminoni
  929. J. Calderwood
  930. D. Greenhough
  931. C. DeSouza
  932. Lisa Muthern
  933. C. Orkin
  934. S. Murphy
  935. M. Truvedi
  936. K. McLean
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  941. S. McCormack
  942. W. Lynn
  943. M. Bevan
  944. J. Fox
  945. A. Teague
  946. J. Anderson
  947. S. Mguni
  948. F. Post
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  950. C. Mazhude
  951. H. Russell
  952. R. Gilson
  953. G. Carrick
  954. J. Ainsworth
  955. A. Waters
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  957. M. Johnson
  958. S. Fidler
  959. K. Kuldanek
  960. S. Mullaney
  961. V. Lawlor
  962. R. Melville
  963. A. Sukthankar
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  966. E. Wilkins
  967. S. Ahmad
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  969. S. Tayal
  970. E. Ong
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  972. L. Riddell
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  997. S. Chandramani
  998. S. Rajamanoharan
  999. T. Robinson
  1000. B. Taylor
  1001. C. Brewer
  1002. Christoph Mayr
  1003. Wolfgang Schmidt
  1004. Andrea Speidel
  1005. Frank Strohbach
  1006. Keikawus Arastéh
  1007. Christiane Cordes
  1008. Manfred Stündel
  1009. Jörg Claus
  1010. Axel Baumgarten
  1011. Andreas Carganico
  1012. Patrick Ingiliz
  1013. Stephan Dupke
  1014. Matthias Freiwald
  1015. Michael Rausch
  1016. Arend Moll
  1017. Dorothea Schleehauf
  1018. Bettina Hintsche
  1019. Gerd Klausen
  1020. Heiko Jessen
  1021. Arne Jessen
  1022. Siegfried Köppe
  1023. Peter Kreckel
  1024. Dietmar Schranz
  1025. Klaus Fischer
  1026. Hubert Schulbin
  1027. Miriam Speer
  1028. Tobias Glaunsinger
  1029. Thomas Wicke
  1030. Bernhard Bieniek
  1031. Heribert Hillenbrand
  1032. Frank Schlote
  1033. Elke Lauenroth-Mai
  1034. Christoph Schuler
  1035. Dirk Schürmann
  1036. Hans Wesselmann
  1037. Norbert Brockmeyer
  1038. Peter Gehring
  1039. Dirk Schmalöer
  1040. Martin Hower
  1041. Petra Sp*rnraft-Ragaller
  1042. Dieter Häussinger
  1043. Stefan Reuter
  1044. Stefan Esser
  1045. Rudolf Markus
  1046. Burkhard Kreft
  1047. Dirk Berzow
  1048. Andreas Christl
  1049. Andreas Meyer
  1050. Andreas Plettenberg
  1051. Albrecht Stoehr
  1052. Katrin Graefe
  1053. Thore Lorenzen
  1054. Axel Adam
  1055. Knut Schewe
  1056. Lutwin Weitner
  1057. Stefan Fenske
  1058. Stefan Hansen
  1059. Hans-Jürgen Stellbrink
  1060. Dorothea Wiemer
  1061. Sandra Hertling
  1062. Reinhold Schmidt
  1063. Peter Arbter
  1064. Bernd Claus
  1065. Peter Galle
  1066. Hans Jäger
  1067. Eva Jä̈gel-Guedes
  1068. Nils Postel
  1069. Monika Fröschl
  1070. Christoph Spinner
  1071. Johannes Bogner
  1072. Bernd Salzberger
  1073. Jürgen Schölmerich
  1074. Franz Audebert
  1075. Ties Marquardt
  1076. Andreas Schaffert
  1077. Eiko Schnaitmann
  1078. Andreas Trein
  1079. Bernhard Frietsch
  1080. Marcus Müller
  1081. Albrecht Ulmer
  1082. Barbara Detering-Hübner
  1083. Peter Kern
  1084. Franz Schubert
  1085. Günther Dehn
  1086. Maria Schreiber
  1087. Cengiz Güler
  1088. Barbara Gunsenheimer-Bartmeyer
  1089. Daniel Schmidt
  1090. Karolin Meixenberger
  1091. Norbert Bannert
  1092. the Netherlands ATHENA HIV Observational Cohort†
  1093. the BEEHIVE Collaboration†

Анотація

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log <jats:sub>10</jats:sub> increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

Список літератури

  1. L. Råberg M. Stjernman in Ecoimmunology G. Demas R. Nelson Eds. (Oxford Univ. Press 2011) pp. 548–578.
  2. Marc Lipsitch (@mlipsitch) Twitter 15 February 2020 https://twitter.com/mlipsitch/status/1228734360716791815.
  3. C. Wymant C. Fraser F. Blanquart Analysis code for “A highly virulent variant of HIV-1 circulating in the Netherlands” Zenodo version 1 (2021); https://doi.org/10.5281/zenodo.5761935.
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  7. M. Hernán J. Robins Causal Inference: What If (Chapman & Hall/CRC Press 2020).

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